Cayman Chemical DegarelIxacetate 50mg

Supplier:  Cayman Chemical 2406950 MG

A potent antagonist of NPY receptor Y5 (Kis 1.3 0.79 0.74 and 1.4 nM for human rhesus monkey mouse and rat receptors respectively) 7500-fold selective for Y5 over other NPY receptors and lacks activity in a panel of 180 receptors enzymes and ion channels at concentrations up to 1 M increases intracellular calcium in CHO cells expressing the human Y5 receptor in a concentration-dependent manner reduces body weight gain in wild-type and diet-induced obese mice when administered at a dose of 30 mg/kg reduces retroperitoneal fat pad weight epididymal and mesenteric fat pad weights leptin levels and food intake in lean mice fed a high-fat diet

Catalog No. 50-293-3179