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Cayman Chemical DehydrolIthocholIc AcId 100mg
SDP

Catalog No. 502990572
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A major metabolite of lithocholic acid; formed from LCA by CYP3A4; an agonist of TGR5 (EC50 = 0.27 μM), VDR (EC50 = 3 μM), and FXR in cell-based reporter assays; binds to human PXR (IC50 = 15 μM) and activates mouse and human PXRs in cell-based reporter assays at 100 μM; binds to RORγt (Kd = 1.13 μM for the recombinant human ligand-binding domain) and decreases its activity in a cell-based reporter assay at 10 μM; inhibits the differentiation of TH17 cells at 20 μM

Catalog No. 50-299-0572 Supplier Cayman Chemical Supplier No. 29544100 MG
May include imposed supplier surcharges.
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A major metabolite of lithocholic acid; formed from LCA by CYP3A4; an agonist of TGR5 (EC50 = 0.27 μM), VDR (EC50 = 3 μM), and FXR in cell-based reporter assays; binds to human PXR (IC50 = 15 μM) and activates mouse and human PXRs in cell-based reporter assays at 100 μM; binds to RORγt (Kd = 1.13 μM for the recombinant human ligand-binding domain) and decreases its activity in a cell-based reporter assay at 10 μM; inhibits the differentiation of TH17 cells at 20 μM

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