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Cayman Chemical Demethylzeylasteral 10mg
Supplier: Cayman Chemical 2859510 MG
A nortriterpenoid; inhibits UGT1A6 and UGT2B7 (Kis = 0.6 and 17.3 μM, respectively); inhibits growth of BAEs and of human U251 glioma cancer cells in vitro (IC50s = 0.21 and ~6.2 μM, respectively); inhibits tumor growth and neovascularization in vivo in a B16/F10 melanoma allograft mouse model at 30 mg/kg per day; decreases renal proteinuria, lesions, immune cell infiltration, and protein levels of TNF-α, COX-2, and ICAM-1 in lupus-prone MRL/lpr mice at 0.12 mg/kg per day; increases kidney transplant survival in recipient rats at 10 mg/kg per day
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