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Cayman Chemical DerazntInIb 10mg
Supplier: Cayman Chemical 2763610 MG
A multi-kinase inhibitor; a pan inhibitor of FGFR (IC50s = 4.5, 1.8, 4.5, and 34 nM for FGFR1, -2, -3, and -4, respectively); inhibits 18 tyrosine kinases and the calcium/calmodulin-dependent protein kinase QIK in a panel of 297 kinases (IC50s = 3-31 and 9.7 nM, respectively); decreases phosphorylation of FGFR in COS-1 cells expressing FGFR1, -2, -3, or -4 (IC50s = 10 µM, respectively) and inhibits the growth of 15 cancer cell lines with mutant, amplified, or translocated FGFR (GI50s = 0.1-1.7 µM); reduces tumor growth and decreases tumor protein levels of phosphorylated FGFR, FRS2, and ERK in a SNU-16 mouse xenograft model at 50 and 75 mg/kg
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