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Cayman Chemical DersImelagon 10mg
Supplier: Cayman Chemical 4146810 MG
An MC1R agonist; selectively induces cAMP accumulation in HEK293 cells expressing human MC1R (EC50 = 8.16 nM) over HEK293 cells expressing human MC2R (EC50 = >10,000 nM) but also induces cAMP accumulation in HEK293 cells expressing human MC4R (EC50 = 79.6 nM); increases melanin levels in B16-F1 melanocytes (EC50 = 13 pM); increases eumelanin levels in the hair roots of, and induces coat darkening in, mice at 0.3 or 3 mg/kg per day; decreases bleomycin-induced increases in skin thickness, skin levels of collagen, dermal levels of myofibroblasts, lung weight, and serum levels of PSP-D, adiponectin, Mmp-2, Mmp-3, P-selectin, Tnfr1, and Tnfr2 in a mouse model of bleomycin-induced systemic sclerosis
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