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Cayman Chemical DesloratdIn 100mg
Supplier: Cayman Chemical 16931100 MG
A histamine H1 receptor antagonist (Ki = 0.97 nM) and an active metabolite of loratadine; inhibits calcium flow in neurons and glia in vitro (IC50s = 9.177 and 0.3185 µM, respectively) in a 5-HT2A receptor-dependent manner; reduces ovalbumin-induced sneezing, nose rubbing, eye watering, and congestion in ovalbumin-sensitized guinea pigs at 10 mg/kg; increases the clearance of amyloid-β by microglia and reverses learning and memory deficits in the Morris water maze in the APP/PS1 mouse model of Alzheimer’s disease at 20 mg/kg per day
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