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Medchemexpress LLC DFBTA | 2966044-07-3 | 99.3% | 393.79 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY14633450MG

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DFBTA is an orally active and potent ANO1 (Calcium-activated chloride channel anoctamin-1) inhibitor, with an IC50 of 24 nM. It shows analgesic efficacy for inflammatory pain. For research use only and not sold to patients.

  • Orally active and potent ANO1 inhibitor
  • IC50 of 24 nM for ANO1
  • Shows analgesic efficacy for inflammatory pain
  • Very weak cytotoxicity and cardiotoxicity (HEK293 proliferation IC50 > 30 μM, hERG IC50 > 30 μM)
  • Weak acute toxicity in mice (MLD > 1000 mg/kg)
  • Excellent pharmacokinetics properties with oral bioavailability > 75%
  • Little brain penetration (<1.5% brain/plasma)

Catalog No. 50-003-63886


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