Medchemexpress LLC DGY-06-116 | 2556836-50-9 | 98.6% | 597.11 | 1 ML

Supplier:  Medchemexpress LLC HY13660510MM/1ML

DGY-06-116 is an irreversible covalent, selective Src inhibitor with an IC50 of 3nM. It also demonstrates inhibitory activity against FGFR1. This compound exhibits potent antiproliferative effects in various cancer cell lines, including nonsmall cell lung cancer (NSCLC) and triple negative breast cancer (TNBC), by inhibiting SRC signaling.

• Potent and selective Src inhibitor (IC50: 3 nM)
• Irreversible covalent mechanism
• Inhibits Src kinase activity with an IC50 of 2.6 nM at 1 hour incubation
• Demonstrates antiproliferative effects in H1975, HCC827, and MDA-MB-231 cell lines
• Induces potent SRC binding and inhibition of SRC signaling
• Inhibits p-SRCY416 signaling in NSCLC cells
• Exhibits in vivo efficacy in adult C57B6 mice, inhibiting SRC for an extended duration

Catalog No. 50-003-52316