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Medchemexpress LLC DI-591 | 2245887-38-9 | 98.06% | 585.80 | 5 MG
Supplier: Medchemexpress LLC 5MGHY124602
DI-591 is a potent, high-affinity, and cell-permeable inhibitor of the DCN1-UBC12 interaction. It selectively inhibits the neddylation of cullin 3, with minimal or no effect on other cullin family members.
- Binds to DCN1 and DCN2 with Ki values of 12 nM and 10.4 nM, respectively
- Shows no significant binding to DCN3, DCN4, and DCN5 proteins
- Serves as an excellent probe compound for investigating the role of cullin 3 CRL
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