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Medchemexpress LLC DI-591 | 2245887-38-9 | 98.4% | 585.80 | 10 MG
Supplier: Medchemexpress LLC 10MGHY124602
DI-591 is a potent, high-affinity, and cell-permeable inhibitor of the DCN1-UBC12 interaction. It selectively inhibits neddylation of cullin 3 with minimal effect on other cullin family members, making it an excellent probe compound for investigating the role of cullin 3 CRL in biological processes and human diseases. It also leads to NRF2 protein accumulation and transcriptional activation.
- Binds to DCN1 and DCN2 with high affinity (Ki values of 12 nM and 10.4 nM respectively)
- Shows >1000-fold selectivity over recombinant human DCN3-5 proteins
- Disrupts the association of cellular DCN1 and UBC12 proteins
- Increases mRNA levels of NQO1 and HO1
- Used for research purposes only
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