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Cayman Chemical diABZI STING Agonist 1 (hydrochloride), Purity: ≥98%, CAS: 2138299-34-8, 5 mg
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Catalog No. 502938897
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An activator of the STING pathway; induces secretion of IFN-β in human PBMCs (EC50 = 130 nM); increases serum levels of Ifn-β, Il-6, Tnf, and Cxcl1 in wild-type, but not Sting-/-, mice at 2.5 mg/kg; inhibits the cytopathic effect of HCoV-229E in infected MRC-5 cells (EC50 = 3 nM); decreases the levels of SARS-CoV-2 RNA in primary human bronchial airway epithelial cells in an air-liquid interface assay; decreases tumor volume and increases survival in a CT26 murine colorectal cancer model at 3 mg/kg; this compound is expected to exist in one or both tautomeric forms

Catalog No. 50-293-8897 Supplier Cayman Chemical Supplier No. 280545 MG
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An activator of the STING pathway; induces secretion of IFN-β in human PBMCs (EC50 = 130 nM); increases serum levels of Ifn-β, Il-6, Tnf, and Cxcl1 in wild-type, but not Sting-/-, mice at 2.5 mg/kg; inhibits the cytopathic effect of HCoV-229E in infected MRC-5 cells (EC50 = 3 nM); decreases the levels of SARS-CoV-2 RNA in primary human bronchial airway epithelial cells in an air-liquid interface assay; decreases tumor volume and increases survival in a CT26 murine colorectal cancer model at 3 mg/kg; this compound is expected to exist in one or both tautomeric forms

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