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Medchemexpress LLC Diazo biotin-PEG3-azide | 1339202-33-3 | 95.5% | C33H45N9O7S | 25 MG
Supplier: Medchemexpress LLC 25MGHY140918
Diazo Biotin-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Azide group. This allows it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules that have DBCO or BCN groups. PROTACs themselves consist of two different ligands linked together, one targeting an E3 ubiquitin ligase and the other a specific protein, leveraging the intracellular ubiquitin-proteasome system to degrade target proteins selectively.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Features an azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions
- Undergoes strain-promoted alkyne-azide cycloaddition reactions
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