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Apexbio Technology LLC Didanosine 69655-05-6 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A84105.1
Didanosine is a nucleoside analogue known to inhibit reverse transcriptase enzymes by acting as a competitive inhibitor and terminator of viral DNA elongation Mechanistically didanosine is phosphorylated intracellularly to its active metabolite dideoxyadenosine triphosphate (ddATP) an analog of dATP Incorporation of ddATP into viral DNA by viral reverse transcriptase causes premature termination of DNA synthesis thereby inhibiting retroviral replication Didanosine is frequently employed as an experimental tool in studies examining antiviral activity and resistance mechanisms in retroviral infection models particularly HIV research In vitro assays commonly report IC50 values for didanosine against HIV reverse transcriptase in the range of approximately 0 5 to 10 M varying according to experimental conditions and viral strain sensitivity evaluated
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