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Cayman Chemical DIfelIkefalIntrIfluoROCTA 10mg
Supplier: Cayman Chemical 3454210 MG
A κ-opioid receptor agonist; activates KOR in HEK293 cells expressing the human receptor (EC50 = 0.16 nM in a transactivation assay); inhibits forskolin-induced cAMP production in R1.G1 cells (EC50 = 0.048 nM); selective for KOR over MOR (EC50 = >1 µM in a transactivation assay); reduces acetic acid-induced writhing, as well as GNTI-induced scratching behavior, in mice (ED50s = 0.07 and 0.05 mg/kg, respectively)
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