Sigma Aldrich Difluoromethyl Triflate

Catalog No.	Quantity
79-276-41ML	5 mL
79-276-45ML	1 mL

Catalog No. 79-276-41ML

Supplier: Sigma Aldrich 7927641ML

Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

Difluoromethyl triflate (HCF2OTf) is an easy to handle, air-stable and non-ozone-depleting liquid reagent for difluoromethylation. It can be prepared by reacting trifluoromethyltrimethylsilane (TMSCF3) and triflic acid in the presence of titanium tetrachloride (TiCl4).Difluoromethyl triflate (TfO-CHF2) can be used as a reagent: In difluoromethylation reaction. To prepare difluoromethoxylated heterocycles by reacting with hydroxylated N-based heterocycles. To synthesize trifluoromethylated arenes by treating with diaryliodonium salts in the presence of copper and tetrabutylammonium difluorotriphenylsilicate (TBAT).It allows for a simple method toward the preparation of difluoromethyl ethers and thioethers under basic conditions from alcohols and thiols. Difluoromethyl phenols can also be obtained in a single pot from boronic acids and C-H activation of arenes.

Specifications

• CAS: 81675-81-2
• Molecular Formula: C10H27N4P
• Linear Formula: C10H27N4P
• MDL Number: MFCD00145111
• Quantity: 5 mL
• Synonym: tert-Butylimino-tris(dimethylamino)phosphorane; N'-tert-Butyl-N,N,N',N',N,N-hexamethylphosphorimidic triamide
• Molecular Weight (g/mol): 234.32 g/mol