Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Unclassified Organic Compounds
  6. Sigma Aldrich Difluoromethyl Triflate 

Sigma Aldrich Difluoromethyl Triflate

Catalog No. 7927645ML Shop All MilliporeSigma Sigma Organic Chemistry Products
Encompass
Change view
Click to view available options
Quantity:
1 mL
5 mL
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
79-276-45ML 1 mL
79-276-41ML 5 mL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
Danger
Catalog No. 79-276-45ML Supplier Sigma Aldrich Supplier No. 7927645ML
Only null left
Add to Cart
Add to Cart
Danger

Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

Difluoromethyl triflate (HCF2OTf) is an easy to handle, air-stable and non-ozone-depleting liquid reagent for difluoromethylation. It can be prepared by reacting trifluoromethyltrimethylsilane (TMSCF3) and triflic acid in the presence of titanium tetrachloride (TiCl4).Difluoromethyl triflate (TfO-CHF2) can be used as a reagent: In difluoromethylation reaction. To prepare difluoromethoxylated heterocycles by reacting with hydroxylated N-based heterocycles. To synthesize trifluoromethylated arenes by treating with diaryliodonium salts in the presence of copper and tetrabutylammonium difluorotriphenylsilicate (TBAT).It allows for a simple method toward the preparation of difluoromethyl ethers and thioethers under basic conditions from alcohols and thiols. Difluoromethyl phenols can also be obtained in a single pot from boronic acids and C-H activation of arenes.

Specifications

CAS 1885-46-7
Density 1.584 g/mL at 25°C
Molecular Formula C2HF5O3S
Linear Formula C2HF5O3S
MDL Number MFCD28054469
Quantity 1 mL
Synonym Difluoromethyl trifluoromethanesulfonate; Trifluoromethanesulfonic acid difluoromethyl ester
Molecular Weight (g/mol) 200.08 g/mol
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.