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Medchemexpress LLC Dihydrocoumarin | 119-84-6 | 148.16 | 25 G
Supplier: Medchemexpress LLC 25GHYN1926
Dihydrocoumarin is a compound found in *Melilotus officinalis*. It acts as a yeast Sir2p inhibitor and also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.
- Yeast Sir2p inhibitor
- Inhibits human SIRT1 (IC50 of 208 μM)
- Inhibits human SIRT2 (IC50 of 295 μM)
- Induces concentration-dependent inhibition of SIRT1 in an in vitro enzymatic assay
- Increases cytotoxicity and apoptosis in the TK6 cell line in a dose-dependent manner
- Increases p53 lysine 373 and 382 acetylation in the TK6 cell line
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