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Medchemexpress LLC Dihydrocoumarin (Hydrocoumarin) | 119-84-6 | 148.16 | 50 G
Supplier: Medchemexpress LLC HYN192650G
Dihydrocoumarin is a compound found in Melilotus officinalis. It is a yeast Sir2p inhibitor and also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.
- Found in Melilotus officinalis.
- Yeast Sir2p inhibitor.
- Inhibits human SIRT1 (IC50 of 208 μM) and SIRT2 (IC50 of 295 μM).
- Induces concentration-dependent inhibition of SIRT1 in an in vitro enzymatic assay.
- Increases cytotoxicity and apoptosis in the TK6 cell line in a dose-dependent manner.
- Increases p53 lysine 373 and 382 acetylation in the TK6 cell line.
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