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Medchemexpress LLC Dihydroergocristine (mesylate) | 24730-10-7 | 5 MG
Supplier: Medchemexpress LLC HYN23195MG
Dihydroergocristine mesylate (DHEC mesylate) is a γ-secretase (GSI) inhibitor. It is known for its ability to reduce the production of Alzheimer's disease amyloid-β peptides by binding directly to γ-secretase and Nicastrin.
- Inhibits γ-secretase (GSI)
- Reduces production of amyloid-β peptides
- Binds directly to γ-secretase and Nicastrin with Kd values of 25.7 nM and 9.8 μM, respectively
- Exhibits an IC50 value of 25 μM for inhibiting γ-secretase activity in T100 cells without affecting cell viability
- Inhibits cellular Aβ production
- Causes dose-dependent accumulation of carboxy-terminal fragments of APP (APP-CTFs) in HEK293
- Decreases γ-secretase activity in fibroblast cells
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