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Medchemexpress LLC Dihydroergotamine mesylate | 6190-39-2 | 99.9% | 5 MG
Supplier: Medchemexpress LLC HYB0670A5MG
Dihydroergotamine mesylate is a blood-brain barrier (BBB)-permeable ergot alkaloid used in migraine research. It targets 5-HT Receptors within GPCR/G Protein and neuronal signaling pathways.
- Acts as a 5-HT receptor agonist.
- Reduces cell survival in A549 and NCI-H226 cells.
- Inhibits cell survival in Hep3B, PLC/PRF/5, Huh7, and HepG2 cells.
- Induces mitochondrial morphologic alterations and dysfunction.
- Increases reactive oxygen species (ROS) generation.
- Triggers apoptosis and disrupts ATP production.
- Inhibits STAT3 activation and enhances Mcl-1 protein stability.
- Inhibits tumor growth in HepG2 xenografted mice.
- Reduces Ki67 positive cells, Mcl-1, p-Mcl-1, and p-ERK expression.
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