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Cayman Chemical DIhydroRgocrIstInmSylate 100mg
Supplier: Cayman Chemical 29492100 MG
An HDAC6 inhibitor (IC50 12 nM) selective for HDAC6 over HDAC1 -4 -5 -7 -8 -9 and -11 (IC50s 1 39 19 5 6 91 8 34 1 23 38 2 and 5 12 UM respectively) inhibits HDAC6 in but does not induce cell death of human PC3 prostate 5637 and T24 bladder and murine SM1 melanoma cells in vitro from 0 1-25 UM decreases PD-L1 protein levels in SM1 cells at 5 UM reduces tumor growth and increases the number of intratumoral CD8 CD4 and NK T cells in an SM1 murine melanoma model
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