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Medchemexpress LLC Dihydrostreptomycin sulfate | 5490-27-7 | 99.7% | 500 MG
Supplier: Medchemexpress LLC HYB1241500MG
Dihydrostreptomycin sulfate is the sulfate salt form of Dihydrostreptomycin. It is an aminoglycoside antibiotic with antibacterial effect against Gram-negative bacteria. It exhibits ototoxicity that causes irreversible damage in inner ear hair cells, leading to hearing loss. It blocks mechanoelectric transduction channels, increases intracellular calcium concentrations, and obstructs auditory signal transmission.
- Antibacterial effects against Gram-negative bacteria.
- Exhibits ototoxicity causing irreversible damage to inner ear hair cells, leading to hearing loss.
- Blocks mechanoelectric transduction channels.
- Increases intracellular calcium concentrations.
- Obstructs auditory signal transmission.
- Induces spiral ligament damage in mouse models.
- Promotes proliferation of spiral ligament cells in the mouse cochlea.
- Upregulates the expression of FGF receptors and connexin 43.
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