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Medchemexpress LLC Diltiazem hydrochloride | 33286-22-5 | 99.5% | 450.98 | 500 MG
Supplier: Medchemexpress LLC HY14656500MG
Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist) that interacts with transmembrane segments IIIS6 and IVS6 in the α1 subunit of L-type Ca2+ channels. It causes a dose-dependent inhibition of contractions and Ca2+ influx stimulated by alpha adrenoceptor activation and high-K+ depolarization. In vivo, Diltiazem improves cardiac microcirculation and function in an experimental model of hyperthyroidism in rats and reduces blood pressure in conscious spontaneously hypertensive rats.
- Interacts with L-type calcium channels
- Inhibits contractions and calcium influx
- Improves cardiac microcirculation and function
- Reduces blood pressure and increases heart rate
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