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Medchemexpress LLC DIM-C-pPhOCH3 | 33985-68-1 | 99.4% | 352.43 | 1 ML
Supplier: Medchemexpress LLC HY11149250MG
DIM-C-pPhOCH3 is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor. This product is for research use only.
- Decreases survival and induces apoptosis in RKO colon cancer cells, accompanied by induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein.
- Induces Nur77-independent apoptosis.
- Inhibits cell growth after treatment for 24, 48, or 72 h, with maximum inhibitory response observed after 72 h, leading to considerable cell detachment and dead cells.
- Growth-inhibitory effects after 72 h are accompanied by markers of apoptosis, including PARP cleavage and cleavage of caspase-3, caspase-9, and caspase-8.
- Inhibits tumor growth in athymic nude mice bearing RKO cell xenografts.
- Significantly decreases tumor volumes and final tumor weights compared with corn oil controls in athymic nude mice bearing RKO cell xenografts.
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