Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Dim-c-pphoh | 151358-47-3 | 99.0% | 338.40 | 1 ML
Supplier: Medchemexpress LLC HY11205510MM/1ML
DIM-C-pPhOH is an antagonist of nuclear receptor 4A1 (NR4A1). It inhibits cancer cell growth, mTOR signaling, and induces apoptosis and cellular stress. It also reduces cell proliferation with IC50 values of 13.6 μM for ACHN cells and 13.0 μM for 786-O cells.
- NR4A1 antagonist.
- Inhibits cancer cell growth and mTOR signaling.
- Induces apoptosis and cellular stress.
- Reduces cell proliferation in ACHN and 786-O cells.
- Inhibits NR4A1-regulated expression of survivin, bcl-2, and EGFR.
- Activates AMPKα and inhibits mTOR.
- Decreases expression of β1-integrin protein and mRNA.
- Inhibits migration of MDA-MB-231 and SKBR3 cell lines.
- Inhibits tumor growth in male athymic nude mice.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?