Medchemexpress LLC Dimemorfan phosphate | 36304-84-4 | 99.9% | 100 MG

Supplier:  Medchemexpress LLC HYB2215100MG

Dimemorfan phosphate is a sigma 1 receptor agonist that is utilized as a potent antitussive. It is intended for research use only and is not sold to patients.

• Sigma 1 receptor agonist
• Potent antitussive
• Inhibits fMLP- and PMA-induced ROS production in a concentration-dependent manner.
• Suppresses Mac-1 upregulation in PMA- and fMLP-activated groups.
• Significantly suppresses LPS-induced ROS and NO production, and LPS-induced iNOS protein expression.
• Blocks the degradation of cytosolic Iκ-Bα and nuclear translocation of NF-κB p65, as well as the transcriptional activity of NF-κB.
• Attenuates BAY k-8644-induced convulsive behaviors and increases in c-fos and c-jun protein expression in a dose-dependent manner.
• Suppresses the increase of plasma TNF-α levels and inhibits infiltration of neutrophils and production of oxidative stress induced by LPS in lung and liver.

Catalog No. 50-004-10445