Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000094515

Apexbio Technology LLC Dimethyl malonate 108-59-8 500mg
SDP

Catalog No. 5000094515
Encompass_Preferred

Dimethyl malonate (CAS 108-59-8) is a competitive inhibitor of succinate dehydrogenase (SDH) an essential enzyme in the mitochondrial tricarboxylic acid (TCA) cycle This compound effectively crosses the blood-brain barrier and is hydrolyzed within brain tissue to yield malonic acid which modulates SDH activity and impairs mitochondrial respiration By altering TCA cycle metabolism dimethyl malonate has been shown to reduce neuronal apoptosis It is frequently employed in studies investigating mitochondrial dysfunction mechanisms of neuronal cell death and the pathophysiology of neurodegenerative diseases serving as a useful tool for establishing disease models and exploring potential therapeutic interventions

Catalog No. 50-000-94515 Supplier Apexbio Technology LLC Supplier No. A4710500
May include imposed supplier surcharges.
Add to Cart
Add to Cart

Dimethyl malonate (CAS 108-59-8) is a competitive inhibitor of succinate dehydrogenase (SDH) an essential enzyme in the mitochondrial tricarboxylic acid (TCA) cycle This compound effectively crosses the blood-brain barrier and is hydrolyzed within brain tissue to yield malonic acid which modulates SDH activity and impairs mitochondrial respiration By altering TCA cycle metabolism dimethyl malonate has been shown to reduce neuronal apoptosis It is frequently employed in studies investigating mitochondrial dysfunction mechanisms of neuronal cell death and the pathophysiology of neurodegenerative diseases serving as a useful tool for establishing disease models and exploring potential therapeutic interventions

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.