Dimethyl malonate, 98+%

Description

CAS: 108-59-8 | C5H8O4 | 132.115 g/mol

Dimethyl malonate is a reagent used in organic synthesis. It acts as a precursor for the synthesis of mono-substituted and di-substituted acetic acid, barbiturates, vitamin B1 and vitamin B6. It is used in the pharmaceutical industry to prepare pharmaceuticals like chloroquine and butazolidin. It is involved in the synthesis of diastereomeric pure thienylpyridines by reacting with 1,3-diphenylprop-2-enyl acetate.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Dimethyl malonate is a reagent used in organic synthesis. It acts as a precursor for the synthesis of mono-substituted and di-substituted acetic acid, barbiturates, vitamin B1 and vitamin B6. It is used in the pharmaceutical industry to prepare pharmaceuticals like chloroquine and butazolidin. It is involved in the synthesis of diastereomeric pure thienylpyridines by reacting with 1,3-diphenylprop-2-enyl acetate.

Solubility
Miscible with alcohol, ether and oils. Slightly miscible with water.

Notes
Incompatible with acids, bases, oxidizing agents and reducing agents.

Specifications

Chemical Identifiers

• CAS: 108-59-8
• Molecular Formula: C5H8O4
• Molecular Weight (g/mol): 132.115
• MDL Number: MFCD00008460
• InChI Key: BEPAFCGSDWSTEL-UHFFFAOYSA-N
• Synonym: dimethyl malonate, methyl malonate, propanedioic acid, dimethyl ester, malonic acid dimethyl ester, 1,3-dimethyl propanedioate, dimethyl 1,3-propanedioate, malonic acid, dimethyl ester, unii-em8y79998c, ccris 8981, propanedioic acid dimethyl ester
• PubChem CID: 7943
• IUPAC Name: dimethyl propanedioate
• SMILES: COC(=O)CC(=O)OC

• Melting Point: -62°C
• Density: 1.156
• Boiling Point: 180°C to 181°C
• Flash Point: 90°C (194°F)
• Refractive Index: 1.413
• Quantity: 100 g
• Beilstein: 774261
• Merck Index: 14,6096
• Solubility Information: Miscible with alcohol,ether and oils. Slightly miscible with water.
• Formula Weight: 132.12
• Percent Purity: ≥98%
• Chemical Name or Material: Dimethyl malonate

Safety and Handling

Hazard Category	H227-H320
Hazard Statement	GHS H Statement H227 Combustible liquid.
Precautionary Statement	P210-P233-P240-P241-P242-P243-P264b-P280-P305+P351+P338-P374-P501c
EINECSNumber	203-597-8
RTECSNumber	OO0950000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only