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Medchemexpress LLC Dimethylamino Parthenolide | 791595-09-0 | 98.0% | 293.40 | 50 MG
Supplier: Medchemexpress LLC HY1617250MG
DMAPT (Dimethylamino Parthenolide) is an analogue of Parthenolide (PTL). It is an oral active NF-κB inhibitor with an LD50 of 1.7 μM for cell populations in AML cells. It exhibits potential anti-cancer and anti-metastatic effects.
- Analogue of Parthenolide (PTL).
- Oral active NF-κB inhibitor.
- LD50 of 1.7 μM for cell populations in AML cells.
- Potential anti-cancer and anti-metastatic effects.
- Decreases constitutive NF-κB binding activity.
- Inhibits cell proliferation and viability of PC-3 and DU145 cells.
- Increases sensitivity of PC-3 tumor xenografts to X-rays in vivo.
- Slows normal tumor development in TRAMP mice.
- Reduces metastatic area in lung tissues.
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