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Apexbio Technology LLC Dinaciclib (SCH727965)(Synonyms: SCH-727965, SCH727965, Dinaciclib, MK-7965, MK7965), 10mM (in 1mL DMSO), CAS: 779353-01-4.
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Supplier:  Apexbio Technology LLC A84125.1

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Dinaciclib (SCH727965 CAS 779353-01-4) is a small-molecule inhibitor targeting cyclin-dependent kinases (CDKs) specifically CDK1 CDK2 CDK5 and CDK9 It exhibits inhibitory potencies with IC50 values of 3 nM for CDK1 1 nM for CDK2 and CDK5 and 4 nM for CDK9 By suppressing CDK activity dinaciclib interrupts cell cycle progression reduces phosphorylation of retinoblastoma (Rb) protein and triggers apoptosis In addition dinaciclib interacts with the acetyl-lysine binding regions within bromodomains Currently in clinical phases I/II it demonstrates antitumor activity both in vitro and in animal models highlighting its potential applicability in oncology research

Catalog No. 50-000-60156


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