Diosgenin

Description

CAS: 512-04-9 | C27H42O3 | 414.63 g/mol

Diosgenin is the precursor for the semisynthesis of progesterone which in turn was used in early combined oral contraceptive pills. The unmodified steroid has estrogenic activity and can reduce the level of serum cholesterol. Diosgenin has been used in traditional medicine as an antihypercholesterolemia, antihypertriacylglycerolemia, antidiabetes and antihyperglycemia agent. Diosgenin is a steroid sapogenin used in the semi-synthesis of pregnenolone, cortisone, and progesterone. Diosgenin has estrogenic activity and can reduce the level of serum cholesterol.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Diosgenin is the precursor for the semisynthesis of progesterone which in turn was used in early combined oral contraceptive pills. The unmodified steroid has estrogenic activity and can reduce the level of serum cholesterol. Diosgenin has been used in traditional medicine as an antihypercholesterolemia, antihypertriacylglycerolemia, antidiabetes and antihyperglycemia agent. Diosgenin is a steroid sapogenin used in the semi-synthesis of pregnenolone, cortisone, and progesterone. Diosgenin has estrogenic activity and can reduce the level of serum cholesterol.

Solubility
Soluble in chloroform (50 mg/ml), ethanol (83 mg/ml at 25°C), water (<1mg/mL at 25°C), DMSO (<1mg/mL at 25°C), and methanol.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 512-04-9
• Molecular Formula: C27H42O3
• Molecular Weight (g/mol): 414.63
• MDL Number: MFCD00016887,MFCD01002142
• InChI Key: WQLVFSAGQJTQCK-VKROHFNGSA-N
• Synonym: 3-beta-Hydroxy-5-spirostene; Nitogenin
• PubChem CID: 46783391
• IUPAC Name: (1'S,2R,2'S,4'S,5R,7'S,8'R,9'S,12'S,13'R,16'S)-5,7',9',13'-tetramethyl-5'-oxaspiro[oxane-2,6'-pentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosan]-18'-en-16'-ol
• SMILES: C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@@H](O)CC[C@]5(C)[C@H]4CC[C@]23C)O[C@]11CC[C@@H](C)CO1

• Melting Point: 200°C to 206°C
• Color: White
• Quantity: 5 g
• Beilstein: 94582
• Merck Index: 14,3295
• Solubility Information: Soluble in chloroform (50mg/ml),ethanol (83mg/ml at 25°C),water (<1mg/ml at 25°C),DMSO (<1mg/ml at 25°C),and methanol.
• Formula Weight: 414.63
• Physical Form: Powder
• Chemical Name or Material: Diosgenin

Safety and Handling

EINECSNumber	208-134-3
RTECSNumber	WH1450000
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only