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Medchemexpress LLC Diphenhydramine hydrochloride | 147-24-0 | 99.93%
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Supplier:  Medchemexpress LLC 25MGHYB0303R

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Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist exhibiting anti-cholinergic effects. This compound is capable of crossing the ovine blood-brain barrier.

  • Inhibits cisplatin-induced cell death in kidney proximal tubular cells.
  • Inhibits cell viability in CCRF-CEM and Jurkat cells.
  • Induces apoptosis in CCRF-CEM and Jurkat cells.
  • Increases expression of Bad and Bax, and decreases BCL-2 level in PANC-1 cells.
  • Decreases expression of various phosphorylated proteins (p-AKT, p-mTOR, p-FoxO1, p-MDM2, p-NF-ĸB p65, and p-GSK-3) in PANC-1 cells.
  • Inhibits cisplatin-induced kidney toxicity in mice.
  • Reduces mortality in rats with acute, severe dichlorvos exposure.

Catalog No. 50-004-50630


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