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Medchemexpress LLC Diprotin A TFA | 209248-71-5 | 99.6% | 455.47 | 50 MG
Supplier: Medchemexpress LLC HY111174A10MM/1ML
Diprotin A TFA (Ile-Pro-Ile TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV) for research use only. It increases the phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells and disrupts endothelial cell-to-cell junctions. In in vivo models, it has been shown to increase retinal vascularity and leakage, and aggravate vascular leakage in diabetic retinopathy by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
- Inhibits dipeptidyl peptidase IV (DPP-IV).
- Increases phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells.
- Disrupts endothelial cell-to-cell junctions.
- Induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
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