Dipyridamole

Description

An inhibitor of adenosine transport and phosphodiesterase | CAS: 58-32-2 | C24H40N8O4 | 504.636 g/mol

Dipyridamole prevents platelets sticking to the replacement heart valve and causing a blood clot on the valve. It is used to dilate blood vessels in people with peripheral arterial disease and coronary artery disease. This compound has been shown to suppress high glucose-induced osteopontin mRNA expression and protein secretion, as well as inhibit cAMP and cGMP hydrolysis. Research indicates that Dipyridamole is a non-specific nucleoside transport inhibitor with the ability to increase the effects of adenosine in sinoatrial and atrioventricular nodes. Dipyridamole is an inhibitor of ENT1 and ENT2.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Dipyridamole prevents platelets sticking to the replacement heart valve and causing a blood clot on the valve. It is used to dilate blood vessels in people with peripheral arterial disease and coronary artery disease. This compound has been shown to suppress high glucose-induced osteopontin mRNA expression and protein secretion, as well as inhibit cAMP and cGMP hydrolysis. Research indicates that Dipyridamole is a non-specific nucleoside transport inhibitor with the ability to increase the effects of adenosine in sinoatrial and atrioventricular nodes. Dipyridamole is an inhibitor of ENT1 and ENT2.

Solubility
Soluble in chloroform, methanol, dilute acids, ethanol. Slightly soluble in water.

Notes
Store in a cool dry place. Keep away from oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 58-32-2
• Molecular Formula: C24H40N8O4
• Molecular Weight (g/mol): 504.636
• MDL Number: MFCD00010555
• InChI Key: IZEKFCXSFNUWAM-UHFFFAOYSA-N
• Synonym: dipyridamole, dipyridamine, persantin, dipyridamol, dipyudamine, persantine, curantyl, stimolcardio, cardoxin, kurantil
• PubChem CID: 3108
• ChEBI: CHEBI:4653
• IUPAC Name: 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol
• SMILES: C1CCN(CC1)C2=NC(=NC3=C2N=C(N=C3N4CCCCC4)N(CCO)CCO)N(CCO)CCO

• Melting Point: 165°C to 167°C
• Color: Yellow
• Quantity: 5 g
• Merck Index: 14,3346
• Solubility Information: Soluble in chloroform,methanol,dilute acids,ethanol. Slightly soluble in water.
• Formula Weight: 504.63
• Physical Form: Powder
• Chemical Name or Material: Dipyridamole

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber	200-374-7
RTECSNumber	KK7450000
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only