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Apexbio Technology LLC Disodium (R)-2-Hydroxyglutarate 103404-90-6 100mg
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Supplier:  Apexbio Technology LLC B6018100

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Disodium (R)-2-Hydroxyglutarate (CAS 103404-90-6) is an enantiomer of 2-hydroxyglutarate that functions as an inhibitor of ATP synthase a rotary enzyme complex critical for ATP production via oxidative phosphorylation Studies have shown that (R)-2-hydroxyglutarate accumulates in human cancers harboring IDH1 or IDH2 mutations where it suppresses ATP synthase activity leading to tumor cell growth arrest and cell death particularly under glucose-limited conditions In IDH-mutant glioma cells elevated (R)-2-hydroxyglutarate levels reduce oxygen consumption linked to ATP synthase This molecule is used to investigate metabolic vulnerabilities in malignancies with altered 2-hydroxyglutarate metabolism and the role of ATP synthase in cancer cell survival

Catalog No. 50-000-88332


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