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Cayman Chemical DIsuccInImIdyl Glutarate 25mg
Supplier: Cayman Chemical 2064625 MG
A dual inhibitor of EGFR and HER2 (IC50s 92 and 59 nM respectively) selective for EGFR and HER2 over a panel of 12 kinases (IC50s 5000 nM) but does inhibit VEGFR2 and Src (IC50s 800 and 1400 nM respectively) inhibits the proliferation of NCI H508 colorectal cancer cells expressing wild-type or mutant forms of HER2 (IC50s 0 2-3 nM) reduces tumor growth in BT474 breast and SKOV3 ovarian cancer mouse xenograft models at 40 mg/kg
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