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Apexbio Technology LLC DL-TBOA(Synonyms: DL-threo-β-Benzyloxyaspartate, DL-threo-beta-Benzyloxyaspartate, DL-TBOA), 5mg, CAS: 205309-81-5.
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Supplier:  Apexbio Technology LLC B50845

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DL-TBOA (CAS 205309-81-5) is a small molecule inhibitor targeting the sodium-dependent glutamate/aspartate transporters also known as excitatory amino acid transporters (EAATs) It competitively inhibits glutamate uptake by EAAT1 and EAAT2 demonstrating Ki values of approximately 42 M and 5 7 M respectively In vitro studies using EAAT-expressing COS-1 cells confirm inhibition of radiolabeled glutamate uptake In vivo microdialysis experiments reveal that DL-TBOA administration significantly elevates extracellular glutamate and aspartate levels causing dose-dependent neuronal damage and seizures DL-TBOA serves as a research tool in neuroscience to study glutamate-mediated neurotoxicity and transporter function

Catalog No. 50-000-60922


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