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Cayman Chemical DLIn-MC3-DMA 50mg
Supplier: Cayman Chemical 3436450 MG
An ionizable cationic lipid (apparent pKa = 6.44); has been used in the generation of lipid nanoparticles (LNPs) encapsulating siRNA, mRNA, or plasmid DNA for use in vitro and in vivo; LNPs containing DLin-MC3-DMA accumulate in the muscle and non-draining lymph nodes after intramuscular administration and in the spleen after intravenous administration in mice; LNPs containing DLin-MC3-DMA and encapsulating F7 siRNA reduce hepatic and plasma Factor VII levels in mice without inducing liver toxicity
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