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AdipoGen DLK1 human pAb
Supplier: AdipoGen AG25A0092C100
Polyclonal Antibody. Recognizes human DLK1. Detects a band of ~42kDa by Western blot. Weakly cross-reacts with mouse Dlk1. Source Rabbit. Applications ELISA, IHC, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. The transmembrane and secreted protein delta-like 1 homolog DLK1 Protein delta homolog 1 Preadipocyte factor 1 Pref-1 belongs to the EGF-like family. It can be cleaved by a tumor necrosis factor-alpha converting enzyme TACE to release a soluble form. DLK1 plays important roles in regulating cell differentiation such as adipogenesis and osteogenesis. Membrane-bound DLK1 promotes hypertrophic myotube formation, whereas soluble DLK1 inhibits myotube formation. The soluble form of DLK1 inhibits preadipocyte differentiation, while membrane DLK1 represses preadipocyte proliferation. DLK1 is also associated with tumor invasion.
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