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Medchemexpress LLC Dma-135 hydrochloride | 2237925-62-9 | 98.0% | C16H18ClN7O | 100 MG
SDP

Supplier:  Medchemexpress LLC HY145932100MG

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DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. It binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (KD= 520 nM) and has no significant toxicity in cell-based studies.

  • Inhibits enterovirus 71 (EV71) IRES-dependent translation and replication
  • Binds to EV71 SLII domain with moderate affinity (KD= 520 nM)
  • No significant toxicity in cell-based studies
  • Induces conformational changes in RNA structure
  • Stabilizes DMA135-RNA-AUF1 ternary complex
  • Inhibits EV71 with an IC50 of 7.54 μM

Catalog No. 50-003-55995


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