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Medchemexpress LLC DMA-135 hydrochloride | 2237925-62-9 | 98.0% | C16H18ClN7O | 25 MG
Supplier: Medchemexpress LLC 25MGHY145932
DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication by binding to the EV71 SLII domain with moderately high affinity (KD= 520 nM). It induces conformational changes in RNA structure, stabilizing the ternary complex DMA135-RNA-AUF1, thereby inhibiting the translation and replication of EV71 with an IC50 of 7.54 μM. Cell-based studies indicate no significant toxicity.
- Inhibits enterovirus 71 (EV71) IRES-dependent translation
- Inhibits enterovirus 71 (EV71) replication
- Binds to EV71 SLII domain with moderately high affinity (KD= 520 nM)
- Induces conformational changes in RNA structure
- Stabilizes the ternary complex DMA135-RNA-AUF1
- No significant toxicity in cell-based studies
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