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Medchemexpress LLC DMA-135 hydrochloride | 2237925-62-9 | 98.0% | C16H18ClN7O | 50 MG
Supplier: Medchemexpress LLC HY14593250MG
DMA-135 hydrochloride is an inhibitor targeting enterovirus 71 (EV71) IRES-dependent translation and replication. It binds to the EV71 SLII domain with moderately high affinity (KD= 520 nM) and shows no significant toxicity in cell-based studies. It induces conformational changes in the RNA structure and stabilizes the ternary complex DMA135-RNA-AUF1, inhibiting the translation and replication of EV71 with an IC50 of 7.54 μM.
- Targets enterovirus 71 (EV71) IRES-dependent translation and replication.
- Binds to the EV71 SLII domain with moderately high affinity.
- Induces conformational changes in RNA structure.
- Stabilizes the ternary complex DMA135-RNA-AUF1.
- Inhibits translation and replication of EV71 with an IC50 of 7.54 μM.
- Demonstrates no significant toxicity in cell-based studies.
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