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AdipoGen DMAPB (5 mg)
SDP

Supplier:  AdipoGen AGCR13904M005

Encompass_Preferred

Chemical. CAS: 827036-76-0. Formula: C16H25N3O2S. MW: 323.5. Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =114nM). Displays selectivity over other HDACs (IC50=1-8µM). Neuroprotective and anti-neuroinflammatory agent. Reduced neuronal degeneration after traumatic brain injury (TBI). Shown to increase histone H3 acetylation. HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.

Catalog No. 50-205-4203


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