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Cayman Chemical DNA MethyltrnsfRase 1 Monc 1ea
Supplier: Cayman Chemical 134791 EA
Antigen: synthetic peptide corresponding to amino acids 637-650 of human DNMT1 • Host: mouse, clone 60B1220.1 • Isotype: IgG1κ • Cross Reactivity: (+) human, mouse, and zebrafish DNMT1 • Application(s): ChIP, IHC (paraffin-embedded sections), IP, and WB • DNMT1 is constitutively expressed in proliferating cells. DNMT1 cooperates with retinablastoma tumor suppressor to repress transcription from promoters containing E2F-binding sites suggesting a link between DNA methylation and cancer cell proliferation.
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