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Genscript Corporation DNAM-1/CD226 Fc Chimera Human
Supplier: Genscript Corporation Z0345450
DNAM-1 (DNAX accessory molecule-1) also known as CD226 platelet and T cell activation antigen 1 (PTA1) and TLiSA1 is a member of the Ig superfamily containing two Ig-like domains of the V set and is encoded by a gene on human chromosome 18q22 3 DNAM-1 is an activating receptor expressed on natural killer (NK) cells CD8 T cells and other immune cells Upon recognition of its ligands CD155 and CD112 DNAM-1 promotes NK cell mediated elimination of transformed and virus-infected cells It also has a key role in expansion and maintenance of virus-specific memory NK cells DNAM-1 is the cell surface receptor of NECTIN2 Upon ligand binding it stimulates T cell proliferation and cytokine production including that of IL2 IL5 IL10 IL13 and IFNG
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