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Cayman Chemical DNARNA OxIdatIve DamageClo
Supplier: Cayman Chemical 401132500 DTN
A furanocoumarin with diverse biological activities a JAK2 and JAK3 inhibitor (IC50s 9.51 and 25.2 UM respectively) selective for JAK2 and JAK3 over TYK2 and JAK1 (IC50s 667 and 2000 UM respectively) induces apoptosis and mitochondrial membrane depolarization in HL-60 cells at 40 and 60 UM induces cell cycle arrest at the G0/G1 phase in HL-60 cells at 10 20 and 40 UM decreases acetic acid-induced writhing and vascular permeability in mice at 100 mg/kg increases the duration of pentobarbital-induced sleep in mice at 10 or 30 mg/kg reduces joint swelling inhibits decreased talus bone volume and reduces meniscus and talus osteoclast numbers in a mouse model of collagen-induced arthritis at 20 mg/kg per day
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