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New England Biolabs, Inc. DNase I-XT-1000 units
Supplier: New England Biolabs, Inc. M0570S
An engineered variant of DNase I DNase I-XT is a salt-tolerant DNA endonuclease that nonspecifically cleaves DNA to release di- tri- and oligonucleotide products with 5 prime phosphorylated and 3 prime hydroxylated ends. DNase I-XT acts on single- and double-stranded DNA chromatin and the DNA strand of RNADNA hybrids. While DNase I (M0303) is inhibited by salt concentrations greater than 50 mM DNase I-XT exhibits optimal activity between 50-100 mM salt and retains 65% and about 40% activity in 200 and 300 mM salt respectively. This increased salt tolerance makes DNase I-XT the preferred enzyme for DNA template removal from an in vitro transcription (IVT) reaction. Importantly DNase I-XT is RNase-free allowing for the complete removal of DNA from RNA preparations while maintaining RNA integrity.
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