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Innovative Research Inc Dog IgM Kit
Supplier: Innovative Research Inc ICNIL1BR5UG
Canine Interleukin-1 Beta (IL-1b) Recombinant 5ug - has been recombinantly produced in yeast and purified using ion-exchange chromatography. This is a loyphilized powder with a purity of greater than 95% as determined by SDS-PAGE analysis. This product is endotoxin free, naturally folded, and pos-translationally modified. It can be used in cell culture, as an ELISA Standard for IL-1b, and as a Western Blot control. IL-1b is syntheszied as a precursor form protein following stimulation of innate immune cells by Toll-like receptors or RIG-like receptors. The IL-1b precursor needs to be cleaved by caspase-1 in order to induce binding abilities, and caspase needs to be activated by the inflammasome (mediated by sytoplasmic pattern recognition receptor signaling). As a result, the secretion of IL-1b is dependent on the necessary steps and activation of the appropriate receptors in order to become active itself.
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