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Medchemexpress LLC Donepezil Hydrochloride | 120011-70-3 | 99.9% | C24H30ClNO3 | 25 MG
Supplier: Medchemexpress LLC 25MGHYB0034
Donepezil Hydrochloride is a reversible, selective acetylcholinesterase (AChE) inhibitor with an IC50 of 6.7 nM. It demonstrates high selectivity for AChE over butyrylcholinesterase (BuChE) and offers neuroprotective effects against Aβ42 neurotoxicity. Its mechanism involves enhanced phosphorylation of Akt and GSK-3β, alongside reduced phosphorylation of tau and glycogen synthase.
- Reversible, selective AChE inhibitor
- High selectivity for AChE over BuChE
- Neuroprotective effects on Aβ42 neurotoxicity
- Enhances phosphorylation of Akt and GSK-3β
- Reduces phosphorylation of tau and glycogen synthase
- Prevents scopolamine-induced memory impairment in mice
- Increases cell viability in cortical neuronal cells
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