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Medchemexpress LLC Donepezil Hydrochloride | 120011-70-3 | 99.9% | C24H30ClNO3 | 500 MG
SDP

Supplier:  Medchemexpress LLC HYB0034500MG

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Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. It shows high selectivity for AChE over BuChE and exhibits a neuroprotective effect on Aβ42 neurotoxicity. Its neuroprotective mechanism is related to the enhanced phosphorylation of Akt and GSK-3β and reduced phosphorylation of tau and glycogen synthase.

  • Reversible, selective AChE inhibitor
  • Shows high selectivity for AChE over BuChE
  • Exhibits neuroprotective effect on Aβ42 neurotoxicity
  • Neuroprotective mechanism is related to enhanced phosphorylation of Akt and GSK-3β
  • Reduced phosphorylation of tau and glycogen synthase

Catalog No. 50-004-32835


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